KMID : 1007520220310091197
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Food Science and Biotechnology 2022 Volume.31 No. 9 p.1197 ~ p.1205
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Pectin oligosaccharides improved lipid metabolism in white adipose tissue of high-fat diet fed mice
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Fan Zixin
Chen Xuejiao Liu Tianzhi Yu Qianhui Song Ziqi Wang Fei Li Tuoping
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Abstract
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Impacts of pectin oligosaccharide (POS) got from hawthorn fruitage on adiponectin signaling pathway and white adipose metabolism in mice fed with high-fat control. The results showed that POS significantly inhibited the levels of inflammatory cytokines TNF-¥á and IL-6, and down-regulated expression of CD68. POS dramatically reduced gene expression contents of fatty acid composite concerning enzymes ACC and FAS, as well as TG synthesis-related enzymes SCD-1 and DGAT1 as compared to a high-fat group (HFC). POS dramatically increased expression levels of oxidation-related enzymes of fatty acid ACO, CPT-1, and TG deposition-related enzymes ATGL and HSL as contrast to the high-fat control group. In addition, POS activated adiponectin-mediated AdipoR1/AMPK/PPAR¥á signaling path by upregulating expression levels of AdipoR1, AMPK and PPAR¥á. The results demonstrated that POS can improve lipid metabolism of adipose tissue, and contribute to the creation of functional foods to prevent and treat lipid metabolism disorders.
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KEYWORD
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Hawthorn, Pectin oligosaccharide, White adipose tissue, Adiponectin, Lipid metabolism
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